Cincinnati Reds relievers David Weathers and Rheal Cormier pitched the first three innings of the game, allowing four hits and no runs. Steve Kelly worked three innings and allowed six runs on eight hits.
Infielder Enrique Cruz led the Bats with two hits and a run scored. Jeff Bannon and Caonabo Cosme each went 1-for-3 with a RBI and run scored in the defeat.
Louisville will play an intrasquad game Thursday at the Reds Minor League Complex in Sarasota.
This story was not subject to the approval of the National Association of Professional Baseball Leagues or its clubs.