Starting pitcher Brad Meyers (2-0) also shined for the Chiefs, pitching seven scoreless innings and striking out eight batters with no walks to get his second win of the season.
Aubrey and the Chiefs offense got started early against Bulls righty Jeremy Hall. Gregor Blanco earned a leadoff walk in the first before advancing to second on an uncontested steal. Chris Marrero brought him home with an RBI double three batters later to give Syracuse a 1-0 lead.
Aubrey extended that margin in the next at-bat with his first home run of the day, a blast over the left-centerfield wall. The designated hitter then ripped a line drive home run over the rightfield wall in his next opportunity to put the score at 4-0 in the third inning.
Durham reliever Chris Bootcheck took over at the mound in the fourth, but he couldn't slow the Chiefs' offense. The first four batters he faced reached on two walks, a single and an error. A sacrifice fly and popout brought Aubrey to the plate again, and with runners on first and second, the designated hitter sent another ball over the rightfield wall to put the score at 9-0.
The Bulls trotted Ryan Reid out to the mound in the sixth, but he couldn't contain Aubrey either. The Syracuse batter led off the seventh inning with his fourth home run of the game, only the second time a Chief has done so in franchise history. The only other Chief to hit four home runs in a game was Gene Locklear in 1977.
Adam Fox added the exclamation point with another home run three batters after Aubrey to put the score at 11-0. J.D. Martin closed out the game for the Chiefs, allowing one hit through two innings.
Syracuse and Durham return to the diamond Sunday at 2 p.m. as Chiefs' lefty Tommy Milone takes on Bulls' righty Edgar Gonzalez.