The Royals' No. 2 prospect drilled a three-run blast in the first inning Wednesday, sending Omaha on its way to an 8-4 victory over Albuquerque in Game 1 of the Pacific Coast League semifinals.
Mitch Maier drew a one-out walk in the first and Anthony Seratelli singled before Myers sent Fernando Nieve's next pitch over the right-center field fence.
"I thought it gave us [good momentum]," he said. "The leadoff guy struck out, then there's a walk, a base hit and we had some momentum going. I got a good pitch over the plate, [was] able to put a good swing on it and luckily, it went out.
"When I first hit it, I thought it was way gone. But the wind was blowing in and it just barely got out."
Myers, MLB.com's No. 14 overall prospect, batted .304 with 24 homers and 79 RBIs in 99 games with the Storm Chasers. Add in the 13 homers he slugged for Double-A Northwest Arkansas and he finished one shy of Darin Ruf, who slugged a Minor League-leading 38 for Double-A Reading.
Despite appearing in fewer than 100 PCL games, Myers tied for fourth in the league in homers and ranked 10th in RBIs. In the opener of the best-of-5 series, Myers went 2-for-2, adding a double, two walks and another run scored.
"It was big, especially in Game 1, the biggest game of the series," he said. "Every good game you have, going into the next game you'll feel confident. I feel like it's the same for our team: Have a good win, everybody swinging the bat pretty well and everyone, I think, will come back tomorrow really confident."
Jake Odorizzi (1-0), Kansas City's No. 4 prospect, picked up the win after allowing three runs on five hits and two walks with seven strikeouts over seven innings. He was promoted to Triple-A in mid-May and proceeded to go 11-3 with a 2.93 ERA, striking out 88 and walking 40 over 107 1/3 innings.
The 22-year-old right-hander was coming off his finest month, going 3-2 with a 2.65 ERA in August.
"He pitched really well tonight. Just a couple mistakes, but other than that, real dominant, good pitching," Myers said. "It was a good team win."
Seratelli finished 2-for-4 and scored twice, while Adam Moore delivered an RBI single for Omaha, which hosts Game 2 on Thursday.
Josh Bard, Jerry Sands and Josh Fields homered for the Isotopes, but Nieve lasted two innings and was charged with three runs on three hits and two walks.
In other Pacific Coast League action:
Reno 3, Sacramento 1
Top Diamondbacks prospect Trevor Bauer issued five walks over five innings but allowed just one unearned run on three hits as the Aces took Game 1 of the other semifinal series.
Tyler Bortnick homered and Mike Jacobs and Tyler Kuhn drove in Reno's other runs.
Bruce Billings took the loss, despite giving up two unearned runs on five hits and a walk while striking out 10 over six frames. Gameday box score