Reds No. 14 prospect Neftali Soto went 4-for-4 with a double and two RBIs, but the battle of Ohio rivals went to the Indians.
The 24-year-old first base prospect likely will start the season at Triple-A Louisville, where he hit .245/.313/.400 with 14 homers and 59 RBIs last year.
Mets 5, Nationals 3
Zack Wheeler, MLB.com's No. 8 overall prospect showed promise in his Grapefruit League debut, striking out two while allowing a hit and a walk over two scoreless frames for the Mets.
Cory Mazzoni, New York's No. 15 prospect, fanned three and also yielded one hit in a pair of shutout frames.
Astros 8, Phillies 3
Astros No. 18 prospect Robbie Grossman went 2-for-3 with a double and two RBIs off the bench, combining with Rule 5 Draft pick Nate Freiman to produce half of Houston's runs.
No. 4 prospect Jarred Cosart struck out one in two innings of perfect relief. Gameday box score
Orioles 5, Twins 3
No. 2 overall prospect Dylan Bundy loaded the bases in the fifth inning on two hits and a walk but struck out two and escaped unscathed for Baltimore.
Orioles No. 4 prospect Jonathan Schoop went 1-for-1 with an RBI and a walk as a replacement for second baseman and leadoff man Brian Roberts.
Yankees 8, Braves 3
Zolio Almonte, the Yankees' No. 10 prospect, launched a two-run homer off Jordan Walden to spark a four-run third inning.
Catcher and No. 18 prospect Austin Romine contributed a pair of RBIs for New York, while Braves No. 4 prospect J.R. Graham worked around two walks and a hit in a scoreless sixth inning. No. 16 prospect Evan Gattis homered, doubled and drove in two runs in a losing effort. Gameday box score
Pirates 3, Rays 2
No. 4 overall prospect Wil Myers went 0-for-1 with a walk in a quiet Grapefruit League debut for the Rays.
Acquired with Myers from Kansas City, Rays No. 8 prospect Mike Montgomery allowed two earned runs on five hits and a walk in one inning. Enny Romero, Tampa Bay's No. 6 prospect, struck out one and scattered two hits over two scoreless frames. Gameday box score
Marlins 8, Cardinals 3
Cardinals No. 6 prospect Michael Wacha needed only 21 pitches to get through two solid innings in a loss to the Marlins.
No. 8 prospect Matt Adams played the whole game at first base for St. Louis, going 2-for-4 with two RBIs. No. 4 prospect Trevor Rosental was touched for four earned runs on five hits and two walks in two innings. Gameday box score
Blue Jays 10, Tigers 3
Blue Jays No. 18 prospect Ryan Goins smacked a pinch three-run homer in the seventh inning to defeat Minnesota.
The 25-year-old shortstop hit seven homers in 136 games for Double-A New Hampshire last season.
Rays 3, Red Sox 2
Jose Iglesias, who has only three homers in his three-year professional career, went deep in the Red Sox's loss.
The organization's top prospect, Xavier Bogaerts, chipped in an RBI on a 1-for-2 afternoon before leaving for the World Baseball Classic.
Rays No. 18 prospect Felipe Rivero helped his team hold a slender lead with a scoreless inning in which he struck out one and gave up a hit and a walk. Gameday box score
Giants 4, Angels 1
Giants No. 17 prospect Ricky Oropesa hit an RBI single in his only at-bat against the Angels.
White Sox 9, Dodgers 0
Jared Mitchell went 1-for-3 and scored twice in his Cactus League opener for the White Sox.
Cubs 11, Angels 2
Cubs No. 4 prospect Brett Jackson tripled twice, drove in two runs and scored once in a rout of the Angels.
Javier Baez (No. 1), Junior Lake (No. 9) and Jorge Soler (No. 3) each went 1-for-3 with a run scored, with Soler chipping in an RBI.
Angels No. 2 prospect Nick Maronde retired two batters and was charged with three runs on two hits and a walk in his Cactus League debut. Gameday box score
Mariners 8, Padres 6
Taijuan Walker and Danny Hultzen -- the Mariners' top two prospects -- combined on two scoreless innings. Hultzen struck out two in a perfect fifth.
Padres top prospect Jedd Gyorko built off his big Spring Training debut by going 1-for-3 with two RBIs. Jeudy Valdez sparked a five-run ninth with a two-run homer, finishing 2-for-2 with three RBIs. Gameday box score
Royals 4, Rangers 2
Jurickson Profar, MLB.com's top overall prospect, went 1-for-2 while playing his first game of the spring at second base for the Rangers.
Brandon Wood, who spent last season with the Rockies' Triple-A affiliate, lifted a walk-off two-run homer for the Royals. Gameday box score
Rockies 11, D-backs 2 Rockies No. 7 prospect Tim Wheeler hit a solo homer as part of a 2-for-2 effort and scored twice off the bench.
D-backs No. 5 prospect Adam Eaton went 1-for-2 with an RBI out of the ninth spot in the lineup, but top pfospect Tyler Skaggs gave up four runs -- two earned -- on four hits over 1 2/3 innings. Gameday box score