Second-ranked Marlins prospect Jake Marisnick notched his second four-hit game of the season and scored three runs Friday night, but Jacksonville dropped a 9-8 decision to visiting Mobile.
Christian Yelich, the lone Miami prospect ranked ahead of Marisnick, reached base three times and scored twice.
D-backs farmhand Dustin Martin missed the cycle by a triple for the BayBears, going 4-for-5 with two runs scored.
Pirates No. 4 prospect Gregory Polanco had three RBIs and Mel Rojas went 4-for-5 with a double, triple and two runs scored in Altoona's 3-1 win over Akron.
Nick Kingham, Pittsburgh's 12th-ranked prospect, allowed one run on six hits over six innings to improve to 2-2 with a 3.41 ERA.
Indians No. 9 prospect Jose Ramirez doubled and singled and is hitting .408 over his last 10 games for the Aeros.
Ian Thomas hurled six innings of two-hit ball and struck out six in Mississippi's 2-0 blanking of Chattanooga. The Braves' No. 20 prospect would rank eighth in the Southern League with a 2.69 ERA if he had enough innings to qualify.
Tommy La Stella, Atlanta's 16th-ranked prospect, reached twice for the M-Braves, while Mycal Jones stole his 19th and 20th bases.
Athletics No. 16 prospect Vinnie Catricala had three hits and an RBI to lead Midland to an 8-1 victory at San Antonio.
Dusty Coleman also contributed three hits, stole a base and scored three times for the RockHounds.
Yeisen Asencio was 3-for-4 with a double and a run scored for the Missions, who got a pair of hits from Padres No. 9 prospect Cory Spangenberg.
Yankees No. 10 prospect Ramon Flores collected three hits in Trenton's 4-1 win over New Britain. The Thunder also got a pair of doubles, a single, an RBI and two runs scored from Jose Pirela.
Top Twins prospect Miguel Sano reached base three times and drove in a run for the Rock Cats.
Cardinals No. 19 prospect Tim Cooney struck out nine and scattered seven hits over 5 2/3 innings in Springfield's 4-0 whitewash of Northwest Arkansas.
Cody Stanley drew a bases-loaded walk and singled in another run for the Cards.
Royals No. 5 prospect Orlando Calixte hit safely in his fifth straight game and has scored eight runs over his last 10 contests for the Naturals. Brett Eibner and Roman Hernandez each had two hits for Northwest Arkansas.