| # | DATE | ADD/DEL | PLAYER | TO | FROM |
| 1 | 4/4 | DEL | OF Wynton Bernard | Injured List | Iowa Cubs |
| 2 | 4/4 | DEL | P Alberto Baldonado | Injured List | Iowa Cubs |
| 3 | 4/6 | DEL | P Kyle Ryan | Chicago Cubs | Iowa Cubs |
| 4 | 4/6 | DEL | P Allen Webster | Chicago Cubs | Iowa Cubs |
| 5 | 4/6 | ADD | P Brad Markey | Iowa Cubs | Eugene Emeralds |
| 6 | 4/6 | ADD | P Ryan Williams | Iowa Cubs | Eugene Emeralds |
| 7 | 4/8 | ADD | P Trevor Clifton | Iowa Cubs | Extended Spring |
| 8 | 4/8 | ADD | P Carl Edwards Jr. | Iowa Cubs | Chicago Cubs |
| 9 | 4/8 | DEL | P Brad Markey | Injured List | Iowa Cubs |
| 10 | 4/8 | DEL | P Ryan Williams | Injured List | Iowa Cubs |
| 11 | 4/10 | DEL | P Tim Collins | Chicago Cubs | Iowa Cubs |
| 12 | 4/10 | DEL | INF Cristhian Adames | Injured List | Iowa Cubs |
| 13 | 4/10 | DEL | INF Zack Short | Injured List | Iowa Cubs |
| 14 | 4/11 | ADD | P Alberto Baldonado | Iowa Cubs | Injured List |
| 15 | 4/11 | ADD | OF Wynton Bernard | Iowa Cubs | Injured List |
| 16 | 4/11 | ADD | INF Vimael Machin | Iowa Cubs | Tennesee Smokies |
| 17 | 4/12 | DEL | C Taylor Davis | Chicago Cubs | Iowa Cubs |
| 18 | 4/12 | ADD | C Erick Castillo | Iowa Cubs | Tennessee Smokies |
| 19 | 4/14 | DEL | Brad Markey | Tennessee Smokies | Iowa Cubs |
