Knoxville Smokies Roster & Staff
CHC Transactions
| Date | Transaction |
| 05/05/22 | LHP Bryan King assigned to Myrtle Beach Pelicans from South Bend Cubs. |
| 05/05/22 | LHP Bryan King assigned to Myrtle Beach Pelicans from South Bend Cubs. |
| 05/03/22 | Iowa Cubs activated C Erick Castillo. |
| 05/03/22 | Iowa Cubs released RHP Kevin McCarthy. |
| 05/03/22 | Chicago Cubs selected the contract of RHP Robert Gsellman from Iowa Cubs. |
| 05/03/22 | OF Cole Roederer assigned to Myrtle Beach Pelicans from South Bend Cubs. |
| 05/03/22 | OF Cole Roederer assigned to Myrtle Beach Pelicans from South Bend Cubs. |
| 05/02/22 | DSL Cubs Blue activated RHP Yoendris Gonzalez. |
| 05/02/22 | RHP Yoendris Gonzalez assigned to DSL Cubs Blue. |
| 05/02/22 | Iowa Cubs released RHP Eric Yardley. |
| 05/02/22 | Chicago Cubs optioned LHP Locke St. John to Iowa Cubs. |
| 05/02/22 | Tennessee Smokies transferred RHP Dauris Valdez from the 7-day injured list to the 60-day injured list. |
| 05/02/22 | Chicago Cubs signed free agent RHP Yoendris Gonzalez to a minor league contract. |
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