Knoxville Smokies Roster & Staff
CHC Transactions
| Date | Transaction |
| 05/12/22 | Iowa Cubs placed OF Brennen Davis on the 7-day injured list. |
| 05/12/22 | Iowa Cubs activated RHP Dakota Mekkes from the 7-day injured list. |
| 05/12/22 | IF Grayson Byrd assigned to South Bend Cubs. |
| 05/11/22 | Chicago Cubs recalled RHP Mark Leiter Jr. from Iowa Cubs. |
| 05/11/22 | Myrtle Beach Pelicans activated CF Jacob Wetzel from the 7-day injured list. |
| 05/11/22 | South Bend Cubs placed SS Ed Howard on the 7-day injured list. |
| 05/11/22 | South Bend Cubs activated RF Jonathan Sierra. |
| 05/10/22 | LHP Bryan Hudson assigned to Iowa Cubs from Tennessee Smokies. |
| 05/10/22 | Chicago Cubs selected the contract of 2B Ildemaro Vargas from Iowa Cubs. |
| 05/10/22 | RHP Cam Sanders assigned to Iowa Cubs from Tennessee Smokies. |
| 05/10/22 | LHP Wyatt Short assigned to Tennessee Smokies. |
| 05/10/22 | RHP Cam Sanders assigned to Iowa Cubs from Tennessee Smokies. |
| 05/10/22 | RHP Max Bain assigned to Tennessee Smokies from South Bend Cubs. |
| 05/10/22 | LHP Bryan Hudson assigned to Iowa Cubs from Tennessee Smokies. |
| 05/10/22 | RHP Chris Clarke assigned to Tennessee Smokies from South Bend Cubs. |
| 05/10/22 | RHP Nicholas Padilla assigned to Tennessee Smokies from South Bend Cubs. |
| 05/10/22 | OF Cole Roederer assigned to South Bend Cubs from Myrtle Beach Pelicans. |
| 05/10/22 | RHP Walker Powell assigned to South Bend Cubs from Myrtle Beach Pelicans. |
| 05/10/22 | SS Jake Slaughter assigned to South Bend Cubs. |
| 05/10/22 | RHP Nicholas Padilla assigned to Tennessee Smokies from South Bend Cubs. |
| 05/10/22 | RHP Max Bain assigned to Tennessee Smokies from South Bend Cubs. |
| 05/10/22 | RHP Chris Clarke assigned to Tennessee Smokies from South Bend Cubs. |
| 05/10/22 | OF Cole Roederer assigned to South Bend Cubs from Myrtle Beach Pelicans. |
| 05/10/22 | RHP Walker Powell assigned to South Bend Cubs from Myrtle Beach Pelicans. |
| 05/09/22 | CF Samuel Duarte retired. |
| 05/09/22 | Iowa Cubs placed LHP Stephen Gonsalves on the 7-day injured list. |
| 05/09/22 | Chicago Cubs optioned RHP Adrian Sampson to Iowa Cubs. |
| 05/09/22 | Chicago Cubs recalled 1B Frank Schwindel from Iowa Cubs. |
| 05/09/22 | Chicago Cubs selected the contract of LHP Conner Menez from Iowa Cubs. |
| 05/09/22 | Tennessee Smokies transferred RHP Riley Thompson to the Development List. |
| 05/09/22 | Tennessee Smokies transferred IF Cam Balego to the Development List. |
| 05/09/22 | Tennessee Smokies transferred RHP Ryan Jensen to the Development List. |
| 05/09/22 | LF Alexander Canario assigned to Tennessee Smokies from South Bend Cubs. |
| 05/09/22 | South Bend Cubs activated LHP Didier Vargas. |
| 05/09/22 | South Bend Cubs released OF Edmond Americaan. |
| 05/09/22 | South Bend Cubs activated RHP Jose Albertos from the 7-day injured list. |
| 05/09/22 | LF Alexander Canario assigned to Tennessee Smokies from South Bend Cubs. |
| 05/08/22 | Iowa Cubs placed RHP Luke Farrell on the 7-day injured list. |
| 05/08/22 | RHP Luke Farrell assigned to Iowa Cubs. |
| 05/08/22 | Chicago Cubs optioned 1B Frank Schwindel to Iowa Cubs. |
| 05/08/22 | Chicago Cubs selected the contract of RHP Adrian Sampson from Iowa Cubs. |
| 05/08/22 | Chicago Cubs signed free agent RHP Luke Farrell to a minor league contract. |
| 05/07/22 | Chicago Cubs sent SS Andrelton Simmons on a rehab assignment to Iowa Cubs. |
| 05/07/22 | Tennessee Smokies activated IF Cam Balego. |
| 05/06/22 | OF Nelson Velazquez assigned to Iowa Cubs from Tennessee Smokies. |
| 05/06/22 | OF Nelson Velazquez assigned to Iowa Cubs from Tennessee Smokies. |
| 05/05/22 | RHP Luis Valenzuela retired. |
| 05/05/22 | Chicago Cubs sent LHP Wade Miley on a rehab assignment to Iowa Cubs. |
| 05/05/22 | Iowa Cubs activated LHP Brendon Little from the 7-day injured list. |
| 05/05/22 | sent LHP Wade Miley on a rehab assignment to Iowa Cubs. |