Knoxville Smokies Roster & Staff
CHC Transactions
| Date | Transaction |
| 05/24/22 | RHP Jose Albertos roster status changed by South Bend Cubs. |
| 05/24/22 | SS Ed Howard roster status changed by South Bend Cubs. |
| 05/23/22 | Tennessee Smokies activated LHP Bailey Horn. |
| 05/23/22 | Tennessee Smokies activated LHP Bailey Horn. |
| 05/23/22 | LHP Bailey Horn assigned to Tennessee Smokies from South Bend Cubs. |
| 05/23/22 | RHP Sheldon Reed assigned to South Bend Cubs from Myrtle Beach Pelicans. |
| 05/23/22 | RHP Sheldon Reed assigned to South Bend Cubs from Myrtle Beach Pelicans. |
| 05/23/22 | LHP Bailey Horn assigned to Tennessee Smokies from South Bend Cubs. |
| 05/22/22 | Iowa Cubs placed LHP Conner Menez on the 7-day injured list. |
| 05/22/22 | Chicago Cubs selected the contract of C P.J. Higgins from Iowa Cubs. |
| 05/22/22 | Tennessee Smokies transferred LHP Burl Carraway to the Development List. |
| 05/21/22 | Iowa Cubs placed RHP Ben Leeper on the 7-day injured list. |
| 05/21/22 | Iowa Cubs placed 3B Esteban Quiroz on the 7-day injured list. |
| 05/19/22 | Chicago Cubs sent 2B David Bote on a rehab assignment to Iowa Cubs. |
| 05/19/22 | Chicago Cubs sent 2B David Bote on a rehab assignment to Iowa Cubs. |
| 05/19/22 | LHP Stephen Gonsalves roster status changed by Iowa Cubs. |
| 05/19/22 | LHP Wyatt Short assigned to Iowa Cubs from Tennessee Smokies. |
| 05/19/22 | Tennessee Smokies activated LHP CD Pelham from the 7-day injured list. |
| 05/19/22 | Tennessee Smokies placed 2B Andy Weber on the 7-day injured list. |
| 05/19/22 | LHP Wyatt Short assigned to Iowa Cubs from Tennessee Smokies. |
| 05/19/22 | Myrtle Beach Pelicans activated RHP Frankie Scalzo Jr. from the 7-day injured list. |
| 05/19/22 | Myrtle Beach Pelicans activated LHP Chase Watkins from the 7-day injured list. |
| 05/18/22 | Chicago Cubs optioned RHP Mark Leiter Jr. to Iowa Cubs. |
| 05/18/22 | OF Bradlee Beesley assigned to Tennessee Smokies from South Bend Cubs. |
| 05/18/22 | South Bend Cubs activated IF Grayson Byrd. |
| 05/18/22 | OF Bradlee Beesley assigned to Tennessee Smokies from South Bend Cubs. |
| 05/18/22 | Chicago Cubs signed free agent OF Erbin Jaque to a minor league contract. |
| 05/17/22 | Chicago Cubs sent LF Clint Frazier on a rehab assignment to Iowa Cubs. |
| 05/17/22 | Chicago Cubs selected the contract of CF Brandon Hughes from Iowa Cubs. |
| 05/17/22 | Chicago Cubs optioned LHP Conner Menez to Iowa Cubs. |
| 05/17/22 | 1B Matt Mervis assigned to Tennessee Smokies from South Bend Cubs. |
| 05/17/22 | Chicago Cubs recalled SS Christopher Morel from Tennessee Smokies. |
| 05/17/22 | RHP Jake Reindl assigned to South Bend Cubs from Myrtle Beach Pelicans. |
| 05/17/22 | South Bend Cubs transferred SS Ed Howard from the 7-day injured list to the 60-day injured list. |
| 05/17/22 | 1B Matt Mervis assigned to Tennessee Smokies from South Bend Cubs. |
| 05/17/22 | RHP Jake Reindl assigned to South Bend Cubs from Myrtle Beach Pelicans. |
| 05/16/22 | DSL Cubs Blue released RHP Waimer Fabian. |
| 05/16/22 | DSL Cubs Blue released RHP Edgar Mercedes. |
| 05/16/22 | DSL Cubs Red released OF Elias Fabian. |
| 05/16/22 | DSL Cubs Red released RHP Jose M. Lopez. |
| 05/16/22 | DSL Cubs Red released Starlin Mateo. |
| 05/16/22 | OF Peter Matt retired. |
| 05/14/22 | Myrtle Beach Pelicans activated OF Felix Stevens from the 7-day injured list. |
| 05/14/22 | Myrtle Beach Pelicans activated OF Felix Stevens from the 7-day injured list. |
| 05/14/22 | Myrtle Beach Pelicans activated OF Felix Stevens from the 7-day injured list. |
| 05/14/22 | SS Yeison Santana assigned to South Bend Cubs from Myrtle Beach Pelicans. |
| 05/14/22 | South Bend Cubs activated SS Yeison Santana. |
| 05/14/22 | SS Yeison Santana assigned to South Bend Cubs from Myrtle Beach Pelicans. |
| 05/13/22 | South Bend Cubs placed RHP Jose Albertos on the 7-day injured list. |
| 05/12/22 | 2B Carlos Sepulveda assigned to Iowa Cubs. |