Knoxville Smokies Roster & Staff
CHC Transactions
| Date | Transaction |
| 06/06/22 | RHP Jose Alcila assigned to ACL Cubs. |
| 06/06/22 | OF Raino Coran assigned to ACL Cubs. |
| 06/06/22 | LHP Ben Holmes assigned to ACL Cubs. |
| 06/06/22 | SS Josue Huma assigned to ACL Cubs. |
| 06/06/22 | RHP Starlyn Pichardo roster status changed by ACL Cubs. |
| 06/06/22 | RHP Starlyn Pichardo roster status changed by ACL Cubs. |
| 06/06/22 | ACL Cubs released C Edgar Gamargo. |
| 06/06/22 | South Bend Cubs sent RHP Yovanny Cruz on a rehab assignment to ACL Cubs. |
| 06/06/22 | LHP Wilson Cunningham assigned to ACL Cubs. |
| 06/06/22 | SS Reivaj Garcia assigned to ACL Cubs. |
| 06/06/22 | RHP Gleiber Morales assigned to ACL Cubs. |
| 06/06/22 | LHP Marino Santy assigned to ACL Cubs. |
| 06/06/22 | RHP Tomy Sanchez assigned to ACL Cubs. |
| 06/06/22 | 2B Bryan Serra assigned to ACL Cubs from Cubs Organization. |
| 06/06/22 | DSL Cubs Blue placed RHP Joandy Duran on the 60-day injured list. |
| 06/06/22 | DSL Cubs Blue placed SS Leonel Espinoza on the 60-day injured list. |
| 06/06/22 | DSL Cubs Blue placed OF Wilmer Bolivar on the 60-day injured list. |
| 06/06/22 | RHP Abel Moya assigned to DSL Cubs Blue. |
| 06/06/22 | DSL Cubs Blue placed RHP Ezequiel Alvarez on the 60-day injured list. |
| 06/06/22 | Chicago Cubs sent LHP Conner Menez outright to Iowa Cubs. |
| 06/06/22 | South Bend Cubs sent RHP Yovanny Cruz on a rehab assignment to ACL Cubs. |
| 06/05/22 | Chicago Cubs optioned RHP Caleb Kilian to Iowa Cubs. |
| 06/04/22 | LHP Angel Hernandez assigned to Myrtle Beach Pelicans from ACL Cubs. |
| 06/04/22 | SS Moises Febrillet assigned to DSL Cubs Blue. |
| 06/04/22 | OF Albert Belliard assigned to DSL Cubs Blue. |
| 06/04/22 | SS Sandy Sanchez assigned to DSL Cubs Blue. |
| 06/04/22 | C Jairo Diaz assigned to DSL Cubs Blue. |
| 06/04/22 | RHP David Bracho assigned to DSL Cubs Blue. |
| 06/04/22 | C Dilver Gomez assigned to DSL Cubs Blue. |
| 06/04/22 | C Abel De Leon assigned to DSL Cubs Blue. |
| 06/04/22 | SS Jefferson Rojas assigned to DSL Cubs Blue. |
| 06/04/22 | OF Josefrailin Alcantara assigned to DSL Cubs Blue. |
| 06/04/22 | RHP Diego Dugarte assigned to DSL Cubs Blue. |
| 06/04/22 | RHP Scarlyn Lebron assigned to DSL Cubs Red from DSL Cubs Blue. |
| 06/04/22 | C Carlos Ramos assigned to DSL Cubs Red from DSL Cubs Blue. |
| 06/04/22 | SS Lizardo Ruiz assigned to DSL Cubs Red from DSL Cubs Blue. |
| 06/04/22 | SS Lizardo Ruiz assigned to DSL Cubs Red from DSL Cubs Blue. |
| 06/04/22 | RHP Scarlyn Lebron assigned to DSL Cubs Red from DSL Cubs Blue. |
| 06/04/22 | C Carlos Ramos assigned to DSL Cubs Red from DSL Cubs Blue. |
| 06/04/22 | Iowa Cubs released 2B Robel Garcia. |
| 06/04/22 | Chicago Cubs selected the contract of RHP Caleb Kilian from Iowa Cubs. |
| 06/04/22 | Chicago Cubs optioned RHP Mark Leiter Jr. to Iowa Cubs. |
| 06/04/22 | Chicago Cubs recalled RHP Anderson Espinoza from Tennessee Smokies. |
| 06/04/22 | RHP Alfredo Zarraga assigned to Myrtle Beach Pelicans. |
| 06/04/22 | LHP Angel Hernandez assigned to Myrtle Beach Pelicans from ACL Cubs. |
| 06/04/22 | South Bend Cubs placed RHP Bradford Deppermann on the 7-day injured list. |
| 06/04/22 | South Bend Cubs placed RHP Bradford Deppermann on the 7-day injured list. |
| 06/03/22 | RHP Eligio Paredes assigned to DSL Cubs Blue from DSL Cubs Red. |
| 06/03/22 | RHP Welington Quintero assigned to DSL Cubs Blue from DSL Cubs Red. |
| 06/03/22 | SS Jose Escobar assigned to DSL Cubs Red from DSL Cubs Blue. |