Sugar Land Space Cowboys Roster & Staff
Sugar Land Transactions
| Date | Transaction |
| 05/17/22 | RHP Seth Martinez roster status changed by Sugar Land Space Cowboys. |
| 05/17/22 | C Cesar Salazar assigned to Sugar Land Space Cowboys from Corpus Christi Hooks. |
| 05/17/22 | Houston Astros recalled RHP Seth Martinez from Sugar Land Space Cowboys. |
| 05/15/22 | Houston Astros optioned 1B Niko Goodrum to Sugar Land Space Cowboys. |
| 05/14/22 | Sugar Land Space Cowboys activated RHP Ronel Blanco. |
| 05/13/22 | Houston Astros optioned RHP Seth Martinez to Sugar Land Space Cowboys. |
| 05/12/22 | RHP Seth Martinez roster status changed by Sugar Land Space Cowboys. |
| 05/12/22 | RHP Ronel Blanco roster status changed by Sugar Land Space Cowboys. |
| 05/12/22 | Houston Astros recalled RHP Seth Martinez from Sugar Land Space Cowboys. |
| 05/10/22 | Sugar Land Space Cowboys placed RHP Tyler Ivey on the restricted list. |
| 05/09/22 | Sugar Land Skeeters placed OF Marty Costes on the 7-day injured list. |
| 05/05/22 | Houston Astros optioned LHP Parker Mushinski to Sugar Land Space Cowboys. |
| 05/03/22 | Houston Astros sent RHP Ryan Pressly on a rehab assignment to Sugar Land Space Cowboys. |
| 05/02/22 | SS Ronaldo Urdaneta assigned to FCL Astros from Sugar Land Space Cowboys. |
| 05/02/22 | RHP Jojanse Torres assigned to Corpus Christi Hooks from Sugar Land Space Cowboys. |
| 05/02/22 | Houston Astros optioned RHP Seth Martinez to Sugar Land Space Cowboys. |
| 05/02/22 | RHP Nick Hernandez assigned to Sugar Land Space Cowboys from Corpus Christi Hooks. |
| 05/02/22 | Houston Astros optioned 1B J.J. Matijevic to Sugar Land Space Cowboys. |
| 05/02/22 | Houston Astros optioned RHP Ronel Blanco to Sugar Land Space Cowboys. |
| 05/01/22 | Sugar Land Space Cowboys released LHP Adam Morgan. |