Michael Kelly fired eight innings of one-hit ball Monday night as the Missions blanked Corpus Christi 4-0 in the series opener at Wolff Stadium.
The Hooks (17-20) have managed no more than one run in four of their last eight games.
Corpus Christi's first hit Monday was a lead-off double by Drew Ferguson in the sixth inning. Ferguson has now hit safely in each of his last 12 games.
Kelly, who struck out nine and walked three, retired 22 of the final 24 men he faced. The 24-year-old right-hander threw 72 of 107 pitches for strikes. Kelly (2-1) has worked seven innings or more in three of his last five starts.
Rafael De Paula pitched the ninth, yielding a lead-off infield single to Garrett Stubbs. De Paula faced three in the frame thanks to a 6-4-3 double play.
The first-place Missions (22-15) own a 1.87 May ERA, the best in Minor League Baseball. They are 12-2 this month.
Hooks right-hander Brock Dykxhoorn battled through 5 2/3 innings. The first three Missions to bat in the second scored. An RBI double to right field from Ty France was the pivotal swing in the sequence.
Dykxhoorn (0-3) was chased with two away in the sixth when Stephen McGee lined a two-bagger into the left-field gap, scoring Fernando Perez.
Riley Ferrell finished the game for the Hooks, retiring seven of the eight batters he faced.
Kyle Smith (0-1, 4.03 ERA) gets the ball for Corpus Christi Tuesday night. San Antonio sends Enyel De Los Santos (2-0, 5.05) to the hill.
This story was not subject to the approval of the National Association of Professional Baseball Leagues or its clubs.