Knoxville Smokies Roster & Staff
CHC Transactions
| Date | Transaction |
| 06/21/22 | Iowa Cubs activated RHP Luke Farrell from the 7-day injured list. |
| 06/21/22 | Chicago Cubs optioned RHP Caleb Kilian to Iowa Cubs. |
| 06/21/22 | Chicago Cubs recalled RHP Mark Leiter Jr. from Iowa Cubs. |
| 06/20/22 | SS Reivaj Garcia assigned to Myrtle Beach Pelicans from ACL Cubs. |
| 06/20/22 | RHP Yovanny Cruz assigned to South Bend Cubs from ACL Cubs. |
| 06/20/22 | Chicago Cubs sent LHP Sean Newcomb outright to Iowa Cubs. |
| 06/20/22 | Chicago Cubs recalled OF Nelson Velazquez, , , and from Iowa Cubs. |
| 06/20/22 | Chicago Cubs optioned RHP Adrian Sampson to Iowa Cubs. |
| 06/20/22 | SS Reivaj Garcia assigned to Myrtle Beach Pelicans from ACL Cubs. |
| 06/20/22 | RHP Yovanny Cruz assigned to South Bend Cubs from ACL Cubs. |
| 06/19/22 | Chicago Cubs sent RHP Ethan Roberts on a rehab assignment to Iowa Cubs. |
| 06/19/22 | South Bend Cubs placed C Casey Opitz on the 7-day injured list. |
| 06/18/22 | LHP Didier Vargas assigned to ACL Cubs from South Bend Cubs. |
| 06/18/22 | Chicago Cubs recalled 1B Alfonso Rivas from Iowa Cubs. |
| 06/18/22 | Tennessee Smokies transferred RHP Nicholas Padilla to the Development List. |
| 06/18/22 | Tennessee Smokies activated RHP Riley Thompson. |
| 06/18/22 | LHP Didier Vargas assigned to ACL Cubs from South Bend Cubs. |
| 06/17/22 | Chicago Cubs sent 2B David Bote on a rehab assignment to Iowa Cubs. |
| 06/17/22 | Chicago Cubs sent LF Clint Frazier outright to Iowa Cubs. |
| 06/16/22 | RHP Adrian Santana assigned to DSL Cubs Blue from DSL Cubs Red. |
| 06/16/22 | RHP Adrian Santana assigned to DSL Cubs Blue from DSL Cubs Red. |
| 06/16/22 | Chicago Cubs selected the contract of RHP Adrian Sampson from Iowa Cubs. |
| 06/15/22 | Chicago Cubs recalled RHP Caleb Kilian from Iowa Cubs. |
| 06/15/22 | Myrtle Beach Pelicans placed SS Reginald Preciado on the 7-day injured list. |
| 06/14/22 | Iowa Cubs transferred RHP Dakota Mekkes to the Development List. |
| 06/14/22 | Tennessee Smokies activated RHP Jeremiah Estrada. |
| 06/14/22 | Tennessee Smokies activated RHP Ryan Jensen. |
| 06/14/22 | Tennessee Smokies activated 2B Andy Weber from the 7-day injured list. |
| 06/14/22 | Tennessee Smokies transferred 2B Christian Donahue to the Development List. |
| 06/14/22 | Tennessee Smokies transferred RHP Kyle Johnson to the Development List. |
| 06/14/22 | RHP Gabriel Jaramillo assigned to South Bend Cubs from Tennessee Smokies. |
| 06/14/22 | RHP Jeremiah Estrada assigned to Tennessee Smokies from South Bend Cubs. |
| 06/14/22 | RHP Gabriel Jaramillo assigned to South Bend Cubs from Tennessee Smokies. |
| 06/14/22 | RHP Jeremiah Estrada assigned to Tennessee Smokies from South Bend Cubs. |
| 06/14/22 | South Bend Cubs sent RHP Tanner Jesson-Dalton on a rehab assignment to Myrtle Beach Pelicans. |
| 06/14/22 | 3B BJ Murray Jr. assigned to South Bend Cubs from Myrtle Beach Pelicans. |
| 06/14/22 | RHP Gabriel Jaramillo assigned to South Bend Cubs from Tennessee Smokies. |
| 06/14/22 | RHP Jeremiah Estrada assigned to Tennessee Smokies from South Bend Cubs. |
| 06/14/22 | South Bend Cubs transferred RHP Bailey Reid to the Development List. |
| 06/14/22 | South Bend Cubs sent RHP Tanner Jesson-Dalton on a rehab assignment to Myrtle Beach Pelicans. |
| 06/14/22 | South Bend Cubs released IF Grayson Byrd. |
| 06/14/22 | South Bend Cubs activated RHP Michael McAvene. |
| 06/14/22 | RHP Gabriel Jaramillo assigned to South Bend Cubs from Tennessee Smokies. |
| 06/14/22 | RHP Jeremiah Estrada assigned to Tennessee Smokies from South Bend Cubs. |
| 06/14/22 | 3B BJ Murray Jr. assigned to South Bend Cubs from Myrtle Beach Pelicans. |
| 06/13/22 | SS Liam Spence assigned to ACL Cubs from Myrtle Beach Pelicans. |
| 06/13/22 | Chicago Cubs selected the contract of LHP Eric Stout from Iowa Cubs. |
| 06/13/22 | SS Liam Spence assigned to ACL Cubs from Myrtle Beach Pelicans. |
| 06/12/22 | Iowa Cubs activated RHP Michael Rucker. |
| 06/12/22 | Chicago Cubs optioned RHP Michael Rucker to Iowa Cubs. |