San Antonio Missions Roster & Staff
SD Transactions
| Date | Transaction |
| 04/15/22 | El Paso Chihuahuas activated RHP Kyle Tyler. |
| 04/15/22 | San Diego Padres optioned RHP Kyle Tyler to El Paso Chihuahuas. |
| 04/15/22 | San Diego Padres recalled LHP MacKenzie Gore from El Paso Chihuahuas. |
| 04/15/22 | RHP Mason Fox assigned to San Antonio Missions from Fort Wayne TinCaps. |
| 04/15/22 | San Antonio Missions placed LHP Osvaldo Hernandez on the 7-day injured list. |
| 04/15/22 | RHP Mason Fox assigned to San Antonio Missions from Fort Wayne TinCaps. |
| 04/14/22 | LHP Daniel Camarena assigned to El Paso Chihuahuas. |
| 04/14/22 | San Diego Padres sent RHP Mike Clevinger on a rehab assignment to Lake Elsinore Storm. |
| 04/14/22 | San Diego Padres sent RHP Mike Clevinger on a rehab assignment to Lake Elsinore Storm. |
| 04/14/22 | San Diego Padres signed free agent LHP Daniel Camarena to a minor league contract. |
| 04/13/22 | San Diego Padres recalled RHP Pedro Avila, and from El Paso Chihuahuas. |
| 04/12/22 | RHP Aaron Holiday assigned to Lake Elsinore Storm from ACL Padres. |
| 04/12/22 | RHP Aaron Holiday assigned to Lake Elsinore Storm from ACL Padres. |
| 04/12/22 | RHP Wen-Hua Sung assigned to El Paso Chihuahuas. |
| 04/12/22 | RHP Aaron Holiday assigned to Lake Elsinore Storm from ACL Padres. |
| 04/12/22 | Lake Elsinore Storm placed LHP Mason Feole on the 7-day injured list. |
| 04/12/22 | Lake Elsinore Storm placed LHP Mason Feole on the 7-day injured list. |
| 04/12/22 | RHP Aaron Holiday assigned to Lake Elsinore Storm from ACL Padres. |
| 04/09/22 | LHP Ramon Perez assigned to San Antonio Missions from El Paso Chihuahuas. |
| 04/09/22 | LHP Ramon Perez assigned to San Antonio Missions from El Paso Chihuahuas. |
| 04/08/22 | ACL Padres released CF Taylor Lomack. |
| 04/08/22 | LHP Ramon Perez assigned to El Paso Chihuahuas from San Antonio Missions. |
| 04/08/22 | RHP Jacob Nix assigned to San Antonio Missions from El Paso Chihuahuas. |
| 04/08/22 | Fort Wayne TinCaps placed RHP Chris Lincoln on the 60-day injured list. |
| 04/08/22 | Fort Wayne TinCaps placed RHP Chase Walter on the 7-day injured list. |
| 04/08/22 | Fort Wayne TinCaps placed RHP Carter Loewen on the 60-day injured list. |
| 04/08/22 | Fort Wayne TinCaps placed RHP Jose Geraldo on the 60-day injured list. |
| 04/08/22 | 3B Jonny Homza assigned to San Antonio Missions from Fort Wayne TinCaps. |
| 04/08/22 | SS Justin Lopez assigned to Fort Wayne TinCaps from San Antonio Missions. |
| 04/08/22 | LHP Mason Feole assigned to Lake Elsinore Storm. |
| 04/08/22 | Lake Elsinore Storm placed LHP Matt Lachappa on the 7-day injured list. |
| 04/08/22 | Lake Elsinore Storm placed RHP Jeferson Garcia on the 60-day injured list. |
| 04/08/22 | Lake Elsinore Storm placed LHP Fernando Sanchez on the 7-day injured list. |
| 04/08/22 | San Diego Padres sent RHP Luis Garcia on a rehab assignment to Lake Elsinore Storm. |
| 04/08/22 | Lake Elsinore Storm placed RHP Jesus Lugo on the 7-day injured list. |
| 04/08/22 | Lake Elsinore Storm placed RHP Matthew Swilley on the 7-day injured list. |
| 04/08/22 | Lake Elsinore Storm placed IF Bryan Torres on the 7-day injured list. |
| 04/08/22 | RHP Matthew Swilley assigned to Lake Elsinore Storm. |
| 04/08/22 | San Antonio Missions placed RHP Ethan Routzahn on the 7-day injured list. |
| 04/08/22 | San Antonio Missions placed RHP Efrain Contreras on the 7-day injured list. |
| 04/08/22 | San Antonio Missions placed RHP Ethan Routzahn on the 7-day injured list. |
| 04/08/22 | San Antonio Missions activated SS Korry Howell. |
| 04/08/22 | San Antonio Missions placed 2B Ethan Skender on the 7-day injured list. |
| 04/08/22 | San Antonio Missions transferred C Michael Cantu to the Development List. |
| 04/08/22 | 3B Jonny Homza assigned to San Antonio Missions from Fort Wayne TinCaps. |
| 04/08/22 | LHP Ramon Perez assigned to El Paso Chihuahuas from San Antonio Missions. |
| 04/08/22 | RHP Jacob Nix assigned to San Antonio Missions from El Paso Chihuahuas. |
| 04/08/22 | SS Justin Lopez assigned to Fort Wayne TinCaps from San Antonio Missions. |
| 04/07/22 | RHP Brenden Heiss assigned to Lake Elsinore Storm from ACL Padres. |
| 04/07/22 | SS Marcos Castanon assigned to Lake Elsinore Storm from ACL Padres. |