From the North/South:
I-25, traveling north or south, Exit 223 (Avenida Cesar Chavez SE). Isotope Park is a half mile from the 1-25 on your left side.
From the East/West:
I-40, traveling east or west, will merge with I-25. Use Exit 159 B (Las Cruces) off I-25. Isotope Park is a half mile on your left after exiting.