Buffalo Bisons Roster & Staff
Buffalo Transactions
| Date | Transaction |
| 05/17/22 | Buffalo Bisons placed CF Mallex Smith on the 7-day injured list. |
| 05/16/22 | Toronto Blue Jays optioned 2B Cavan Biggio to Buffalo Bisons. |
| 05/16/22 | Toronto Blue Jays recalled LHP Andrew Vasquez from Buffalo Bisons. |
| 05/15/22 | RHP Max Castillo assigned to Buffalo Bisons from New Hampshire Fisher Cats. |
| 05/14/22 | Buffalo Bisons sent CF Chavez Young on a rehab assignment to Dunedin Blue Jays. |
| 05/14/22 | Toronto Blue Jays optioned RHP Trent Thornton to Buffalo Bisons. |
| 05/14/22 | Toronto Blue Jays optioned C Tyler Heineman to Buffalo Bisons. |
| 05/12/22 | Buffalo Bisons activated C Kellin Deglan. |
| 05/12/22 | 2B LJ Talley assigned to New Hampshire Fisher Cats from Buffalo Bisons. |
| 05/10/22 | Toronto Blue Jays sent 2B Cavan Biggio on a rehab assignment to Buffalo Bisons. |
| 05/09/22 | RHP Andrew Bash assigned to New Hampshire Fisher Cats from Buffalo Bisons. |
| 05/08/22 | Toronto Blue Jays optioned RHP Casey Lawrence to Buffalo Bisons. |
| 05/07/22 | Toronto Blue Jays optioned RHP Julian Merryweather to Buffalo Bisons. |
| 05/06/22 | C Kellin Deglan roster status changed by Buffalo Bisons. |
| 05/05/22 | Toronto Blue Jays sent LHP Hyun Jin Ryu on a rehab assignment to Buffalo Bisons. |
| 05/05/22 | LHP Derek Holland assigned to Buffalo Bisons. |
| 05/05/22 | sent LHP Hyun Jin Ryu on a rehab assignment to Buffalo Bisons. |
| 05/04/22 | Toronto Blue Jays optioned LHP Andrew Vasquez to Buffalo Bisons. |
| 05/04/22 | Toronto Blue Jays selected the contract of RHP Casey Lawrence from Buffalo Bisons. |
| 05/03/22 | Buffalo Bisons activated SS Otto Lopez. |
| 05/03/22 | Buffalo Bisons released CF Dexter Fowler. |
| 05/02/22 | Toronto Blue Jays optioned RHP Bowden Francis to Buffalo Bisons. |
| 05/02/22 | RHP Jake Elliott assigned to New Hampshire Fisher Cats from Buffalo Bisons. |
| 05/02/22 | Toronto Blue Jays optioned 2B Gosuke Katoh to Buffalo Bisons. |