Iowa Cubs Roster & Staff
Iowa Transactions
| Date | Transaction |
| 05/27/22 | LHP Brandon Leibrandt assigned to Iowa Cubs from Tennessee Smokies. |
| 05/24/22 | Iowa Cubs transferred RHP Jonathan Holder from the 7-day injured list to the 60-day injured list. |
| 05/24/22 | Chicago Cubs sent LHP Sean Newcomb on a rehab assignment to Iowa Cubs. |
| 05/24/22 | LHP Steven Brault roster status changed by Iowa Cubs. |
| 05/22/22 | Iowa Cubs placed LHP Conner Menez on the 7-day injured list. |
| 05/22/22 | Chicago Cubs selected the contract of C P.J. Higgins from Iowa Cubs. |
| 05/21/22 | Iowa Cubs placed 3B Esteban Quiroz on the 7-day injured list. |
| 05/21/22 | Iowa Cubs placed RHP Ben Leeper on the 7-day injured list. |
| 05/19/22 | LHP Stephen Gonsalves roster status changed by Iowa Cubs. |
| 05/19/22 | Chicago Cubs sent 2B David Bote on a rehab assignment to Iowa Cubs. |
| 05/19/22 | LHP Wyatt Short assigned to Iowa Cubs from Tennessee Smokies. |
| 05/18/22 | Chicago Cubs optioned RHP Mark Leiter Jr. to Iowa Cubs. |
| 05/17/22 | Chicago Cubs sent LF Clint Frazier on a rehab assignment to Iowa Cubs. |
| 05/17/22 | Chicago Cubs selected the contract of CF Brandon Hughes from Iowa Cubs. |
| 05/17/22 | Chicago Cubs optioned LHP Conner Menez to Iowa Cubs. |
| 05/12/22 | 2B Carlos Sepulveda assigned to Iowa Cubs. |
| 05/12/22 | Iowa Cubs placed OF Brennen Davis on the 7-day injured list. |
| 05/12/22 | Iowa Cubs activated RHP Dakota Mekkes from the 7-day injured list. |
| 05/11/22 | Chicago Cubs recalled RHP Mark Leiter Jr. from Iowa Cubs. |
| 05/10/22 | LHP Bryan Hudson assigned to Iowa Cubs from Tennessee Smokies. |
| 05/10/22 | Chicago Cubs selected the contract of 2B Ildemaro Vargas from Iowa Cubs. |
| 05/10/22 | RHP Cam Sanders assigned to Iowa Cubs from Tennessee Smokies. |
| 05/09/22 | Iowa Cubs placed LHP Stephen Gonsalves on the 7-day injured list. |
| 05/09/22 | Chicago Cubs selected the contract of LHP Conner Menez from Iowa Cubs. |
| 05/09/22 | Chicago Cubs optioned RHP Adrian Sampson to Iowa Cubs. |
| 05/09/22 | Chicago Cubs recalled 1B Frank Schwindel from Iowa Cubs. |
| 05/08/22 | RHP Luke Farrell assigned to Iowa Cubs. |
| 05/08/22 | Chicago Cubs optioned 1B Frank Schwindel to Iowa Cubs. |
| 05/08/22 | Chicago Cubs selected the contract of RHP Adrian Sampson from Iowa Cubs. |
| 05/07/22 | Chicago Cubs sent SS Andrelton Simmons on a rehab assignment to Iowa Cubs. |
| 05/06/22 | OF Nelson Velazquez assigned to Iowa Cubs from Tennessee Smokies. |
| 05/05/22 | Iowa Cubs activated LHP Brendon Little from the 7-day injured list. |
| 05/05/22 | Chicago Cubs sent LHP Wade Miley on a rehab assignment to Iowa Cubs. |
| 05/05/22 | sent LHP Wade Miley on a rehab assignment to Iowa Cubs. |
| 05/03/22 | Iowa Cubs released RHP Kevin McCarthy. |
| 05/03/22 | Iowa Cubs activated C Erick Castillo. |
| 05/03/22 | Chicago Cubs selected the contract of RHP Robert Gsellman from Iowa Cubs. |
| 05/02/22 | Iowa Cubs released RHP Eric Yardley. |
| 05/02/22 | Chicago Cubs optioned LHP Locke St. John to Iowa Cubs. |