Toledo Mud Hens Roster & Staff
DET Transactions
| Date | Transaction |
| 04/06/22 | RHP Chance Kirby assigned to Erie SeaWolves from West Michigan Whitecaps. |
| 04/06/22 | Detroit Tigers signed free agent C Chase Barbary to a minor league contract. |
| 04/05/22 | RHP Carlos Marcano assigned to Lakeland Flying Tigers from DSL Tigers. |
| 04/05/22 | 2B Carlos Mendoza assigned to Lakeland Flying Tigers from Erie SeaWolves. |
| 04/05/22 | SS Manuel Sequera assigned to Lakeland Flying Tigers from FCL Tigers East. |
| 04/05/22 | OF Lazaro Benitez assigned to Lakeland Flying Tigers from FCL Tigers East. |
| 04/05/22 | C Danuerys De La Cruz assigned to Lakeland Flying Tigers from FCL Tigers East. |
| 04/05/22 | RHP Hendry Nunez assigned to Lakeland Flying Tigers from FCL Tigers East. |
| 04/05/22 | OF Jose De La Cruz assigned to Lakeland Flying Tigers from FCL Tigers East. |
| 04/05/22 | RHP Andy Santana assigned to Lakeland Flying Tigers from FCL Tigers East. |
| 04/05/22 | RHP Jack Anderson assigned to Lakeland Flying Tigers from FCL Tigers East. |
| 04/05/22 | RHP Wilkel Hernandez assigned to Lakeland Flying Tigers from West Michigan Whitecaps. |
| 04/05/22 | RHP Garrett Burhenn assigned to Lakeland Flying Tigers from FCL Tigers West. |
| 04/05/22 | OF Jose De La Cruz assigned to Lakeland Flying Tigers from FCL Tigers East. |
| 04/05/22 | RHP Blake Holub assigned to Lakeland Flying Tigers from FCL Tigers West. |
| 04/05/22 | 2B Carlos Mendoza assigned to Lakeland Flying Tigers from Erie SeaWolves. |
| 04/05/22 | OF Elvis Alvarado assigned to Lakeland Flying Tigers from Toledo Mud Hens. |
| 04/05/22 | RHP Jack Anderson assigned to Lakeland Flying Tigers from FCL Tigers East. |
| 04/05/22 | SS Manuel Sequera assigned to Lakeland Flying Tigers from FCL Tigers East. |
| 04/05/22 | RHP Hendry Nunez assigned to Lakeland Flying Tigers from FCL Tigers East. |
| 04/05/22 | LHP Cleiverth Perez assigned to West Michigan Whitecaps from Lakeland Flying Tigers. |
| 04/05/22 | LHP Brant Hurter assigned to Lakeland Flying Tigers from FCL Tigers West. |
| 04/05/22 | OF Lazaro Benitez assigned to Lakeland Flying Tigers from FCL Tigers East. |
| 04/05/22 | 1B Justice Bigbie assigned to Lakeland Flying Tigers from FCL Tigers West. |
| 04/05/22 | RHP Carlos Marcano assigned to Lakeland Flying Tigers from DSL Tigers. |
| 04/05/22 | C Danuerys De La Cruz assigned to Lakeland Flying Tigers from FCL Tigers East. |
| 04/05/22 | RHP Francisco Jimenez assigned to Lakeland Flying Tigers from FCL Tigers West. |
| 04/05/22 | RHP Andy Santana assigned to Lakeland Flying Tigers from FCL Tigers East. |
| 04/05/22 | RHP Tyler Mattison assigned to Lakeland Flying Tigers from Tigers Organization. |
| 04/05/22 | RF Roberto Campos assigned to Lakeland Flying Tigers from FCL Tigers West. |
| 04/05/22 | SS Izaac Pacheco assigned to Lakeland Flying Tigers from FCL Tigers West. |
| 04/05/22 | Toledo Mud Hens placed RHP Ramon Rosso on the temporarily inactive list. |
| 04/05/22 | Detroit Tigers optioned RHP Michael Pineda to Toledo Mud Hens. |
| 04/05/22 | OF Elvis Alvarado assigned to Lakeland Flying Tigers from Toledo Mud Hens. |
| 04/05/22 | RHP Wilkel Hernandez assigned to Lakeland Flying Tigers from West Michigan Whitecaps. |
| 04/05/22 | LHP Cleiverth Perez assigned to West Michigan Whitecaps from Lakeland Flying Tigers. |
| 04/05/22 | Detroit Tigers signed free agent RHP Shea Spitzbarth to a minor league contract. |
| 04/04/22 | LF Dylan Rosa assigned to Toledo Mud Hens from Erie SeaWolves. |
| 04/04/22 | 3B John Valente assigned to Toledo Mud Hens from Erie SeaWolves. |
| 04/04/22 | RHP Beau Brieske assigned to Toledo Mud Hens from Erie SeaWolves. |
| 04/04/22 | 3B John Valente assigned to Toledo Mud Hens from Erie SeaWolves. |
| 04/04/22 | FCL Tigers placed RHP Eliezer Gonzalez on the restricted list. |
| 04/04/22 | FCL Tigers East placed RHP Eliezer Gonzalez on the restricted list. |
| 04/04/22 | RHP Ricardo Pinto assigned to Toledo Mud Hens. |
| 04/04/22 | Toledo Mud Hens activated 3B John Valente. |
| 04/04/22 | Toledo Mud Hens placed OF Riley Greene on the 7-day injured list. |
| 04/04/22 | RHP Alex Powers assigned to Toledo Mud Hens. |
| 04/04/22 | LHP Miguel Del Pozo assigned to Toledo Mud Hens. |
| 04/04/22 | LHP J.T. Perez assigned to Toledo Mud Hens. |
| 04/04/22 | 3B John Valente assigned to Toledo Mud Hens from Erie SeaWolves. |